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6. The aetiology of eating disorders, The British Journal of Psychiatry

(C) 2004 The Royal College of Psychiatrists

Volume 185, November 2004, pp 363-365

The aetiology of eating disorders

COLLIER, D. A.; TREASURE, J. L.
D. A. COLLIER, PhD, Social, Genetic and Developmental Psychiatry Research

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The past decade has seen a major shift in our thoughts about the origins of
eating disorders. Anorexia nervosa has traditionally been regarded as a disorder
with social and cultural explanations, rather than a developmental or biological
disorder (Nasser et al, 2000). For about a century from the first formalisation
of the concept of anorexia nervosa by Lasegue the disorder was regarded as a
non-specific, environmentally responsive neurosis of women with its roots in the
dysfunctional family. Only in the 1970s did anorexia nervosa emerge as a
neurotic syndrome in its own right. At about the same time, bulimia nervosa was
first described by Russell (1979), and since then the prevalence has risen,
sharply outnumbering cases of anorexia nervosa. Descriptions of binge eating
disorder followed soon after. By the 1980s, eating disorders were thought of as
an extreme manifestation of societal obsessions with thinness, with common
subclinical syndromes present in the population. In the 1990s this causality
shifted to gender dynamics, focusing on power and self-determination, rather
than being related to the biology of female gender. Current sociocultural
explanations include worldwide cultural dynamics, such as cultures in transition
('Westernising' societies) and confused gender identities. However, the biggest
change in the perception of eating disorders came in the 1990s, when converging
evidence from twin and family studies showed that they have a genetic component.

Although there is no doubt that these sociocultural explanations are important
and relevant, anorexia, bulimia and obesity are perhaps better regarded as
heterogeneous disorders with complex multifactorial aetiology, involving the
interaction of genes and the environment, particularly social factors. However,
little is known about this aetiology, particularly its biological components,
and this is severely hampering the development of new treatments.

THE PHENOTYPE: WHAT ARE EATING DISORDERS?

The diagnosis of eating disorders is a tricky business: diagnosis can be
unstable, with clinical features changing over time, often switching from
anorexia to bulimia, and there is frequently comorbidity with other diagnoses
such as anxiety and depression (Fairburn & Harrison, 2003). Risk factors can be
common to the two disorders, or distinct, such as dieting. This combination of
overlapping and distinct features makes research into fixed risk factors such as
genes and environmental events difficult to perform.

So how can nosology be improved to better reflect the underlying structure of
eating disorders? There is a lack of empirical evidence for DSM-IV criteria for
eating disorders, and some suggest that they may not adequately describe the key
symptoms (Hebebrand et al, 2004). On the one hand, the modern criteria used to
define the illness have been criticised for overemphasis on pathoplastic
features of eating disorders such as fear of fat, which are absent in many
cases; on the other hand, the tendency to bunch eating disorders together can
mask important differences, such as in eating behaviour itself. For example,
binge eating occurs across the weight spectrum from anorexia nervosa to obesity.
Both eating behaviours and body composition have been used for diagnostic
purposes. In clinical studies, anorexia nervosa - the restricting type - emerges
as a distinct phenotype, and is now subtyped into restricting and binge-purging
subtypes, but transitions between these subtypes are common. Family studies have
found four classes of eating disorders, which cluster in families: restricting
anorexia nervosa, with and without obsessive-compulsive symptoms, a combination
of purging anorexia and bulimia nervosa, and finally bulimia nervosa with
self-induced vomiting (Keel et al, 2004).

Stable phenotypes: a developmental perspective

Given the temporal instability between clinical syndromes which obfuscates
research into fixed markers such as genes, there has been a move to examine more
stable features such as personality and neurobiological traits. These features
precede the onset of the eating disorder and are present in childhood, making
them developmental in origin (Connan et al, 2003). Childhood perfectionism
appears to be a particularly strong antecedent risk factor (Anderluh et al,
2003). Some enduring personality traits appear linked to specific types of
eating behaviours, whereas others are more general (Karwautz et al, 2002). For
example, individuals with both constrained (anorexia) and disinhibited (bulimia)
eating share the personality trait of high harm avoidance. However, novelty-seeking
personality is linked specifically to those who show disinhibited eating
behaviour, as is exploratory excitability, impulsivity and extravagance (Vervaet
et al, 2004). Impulsivity in binge eating is particularly marked in the context
of negative affect. In contrast, constrained eating (as seen in restricting
anorexia nervosa) is linked to compulsivity. It is therefore interesting to note
that including obsessionality as part of the behavioural phenotype of anorexia
nervosa may be a powerful tool for genetic linkage analysis (Devlin et al,
2002). These personality traits may be linked to the underlying neurobiological
template.

Compulsivity may be linked to perceptual and cognitive inflexibility. People
with anorexia nervosa have reduced flexibility in the acute state and, for some
measures, also after recovery (Tchanturia et al, 2004). This appears to be a
familial trait not shared by those with bulimia nervosa, which is associated
with childhood obsessive-compulsive traits. Thus, inflexibility might be an
endophenotype linked to constrained eating. In turn, this inflexibility might
possibly be linked to a difficulty in extinguishing learnt behaviours, a
hypothesis raised by Strober (2004).

Clues also come from neurobiology. The complex links between personality,
biology and environment have been the particular focus of work by Steiger and
colleagues, particularly how serotonergic factors, personality trait variations
and developmental typologies converge (Steiger, 2004). One particular serotonin
receptor, 5-HT2A, has been found to have abnormal levels in recovered patients,
with different diagnostic groups showing differing alterations (Kaye et al,
2001). Thus, abnormalities in central serotonin function vary across the eating
disorder spectrum. The fact that these persist after recovery suggest that
serotonin function might be a traits marker for eating disorders.

GENES

In the 1980s twin studies in anorexia nervosa led to a radical re-evaluation of
the long-standing emphasis on the social and cultural explanations of eating
disorders, and it is now accepted by most that eating disorders have a genetic
component (Bulik et al, 2000). Although it is not possible to draw firm
conclusions on the exact contribution of genes and environment to eating
disorders, it is reasonable to suggest that they contribute to the disorder in
roughly equal measure.

Many traits related to eating disorders also have a heritable component. These
include binge eating, self-induced vomiting, drive for thinness, dietary
restraint and disinhibition (Bulik et al, 2000), several of which are quantitative
traits which can be measured in the normal population. The realisation that
eating disorders have in part a genetic basis has led to molecular studies aimed
at finding genetic vulnerability factors. The driving force behind this is that
almost nothing is known about the aetiology of eating disorders, and the
discovery of susceptibility genes would be an important step in its unravelling.

Molecular genetic analysis has focused on both genome-wide linkage analysis in
multiply affected families in order to try to identify chromosomal loci
harbouring genes, and on candidate gene studies. Genome-wide linkage analysis
has not found loci for the broad diagnostic category of anorexia and bulimia
nervosa, but analysis of pedigrees with at least one pair of relatives with
restricted anorexia nervosa identified linkage to chromosome 1p34 (Grice et al,
2002), consistent with the idea that the latter might be a distinct phenotype.

Quantitative genetics has also been used to try to overcome current diagnostic
limitations. Drive for thinness and obsessionality tracked most closely with
anorexia nervosa, providing novel genetic loci on chromosomes 1 for a composite
measure and 13 for drive for thinness (Devlin et al, 2002). Bulimia nervosa, in
particular the form with self-induced vomiting, has been linked to chromosome 10
(Bulik et al, 2003), strengthening the idea that bulimia with self-induced
vomiting might be a distinct phenotype. Interestingly, this position is also a
known locus for obesity, consistent with the elevated family history of obesity
seen in bulimia nervosa.

Association studies have focused on the genes specifically relating to the
neuro-chemistry of eating behaviour. One such candidate is the serotonin
receptor 5-HT2A gene HTR2A. Candidate gene association analysis has identified a
putative risk allele in this gene, and this has been replicated in some but not
all studies. It is possible that heterogeneity within clinical groups might
explain differences between studies, as there is the suggestion that HTR2A is
associated with constrained rather than disinhibited eating behaviour.
Tantalisingly, HTR2A maps to a chromosome 13 linkage peak for the drive for
thinness phenotype (Devlin et al, 2002).

The brain-derived neurotrophic factor (BDNF) gene has also been implicated as a
susceptibility gene for anorexia nervosa. This protein is involved in regulating
feeding behaviour in the hypothalamus, including the regulation of serotonin
levels, and low levels are implicated in depression. A multicentre European
study found strong evidence that a polymorphism in this gene increases
susceptibility to all eating disorder diagnoses, perhaps through its involvement
in affective symptoms (Ribases et al, 2004).

An alternative approach is to examine models of eating disorders in animals.
Feeding behaviour is similar among mammals, and many animals - including mice
and pigs - display behaviours reminiscent of human eating disorders (Owen et al,
2001). For example, mice and rats given food for only 2 h per day and allowed
access to a running wheel develop behavioural hyperactivity and weight loss
analogous to anorexia nervosa. This points to fundamental mammalian behaviours
that might explain some of the phenotypes seen in human eating disorders, and
which could be dissected by genetic analysis in rodents and used to model new
forms of treatment (Exner et al, 2000).

FUTURE RESEARCH

Increasingly, the consensus is that eating disorders are complex disorders
consisting of both genetic and social factors, with a developmental component
strongly linked to adult illness (Fig. 1). This means that integrated research
into their aetiology, which includes genetic, biological, developmental and
social perspectives, is now realistic. However, many difficulties remain - not
least the problem of defining these disorders in a way that reflects their
underlying features. This approach is beginning to take effect, with the
recognition that restricting anorexia may be a distinct illness with its own
biological basis. However, many commonalities between anorexia and bulimia
remain, including risk factors that appear to be common to all such diagnoses.
Despite this progress, the study of gene-environment interaction has barely been
touched to date. There are many questions that remain to be answered regarding
the aetiology of eating disorders. Which biological pathways are involved? Can a
set of valid diagnoses reflecting underlying aetiology be constructed? Why are
those affected predominantly women? How can the dual influence of genes and
societal pressures be successfully reconciled? What is the exact nature of the
developmental component? How can treatment be improved? The answers to these
questions should become apparent in the coming decade.

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Fig. 1 Empirical structure of eating disorder. Cultural factors include
pervasive factors such as diet and cultural attitudes to weight and shape.
Cognitive style and personality are influenced by both genes and environment.
Correlations exist between biological factors (serotonin function), environment
(adverse childhood experiences), personality (e.g. impulsivity) and affect. All
of these factors are influenced and mediated by genes. RAN, restricting anorexia
nervosa.
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