vivienvixen (vivienvixen) wrote in ed_ucate,
vivienvixen
vivienvixen
ed_ucate

Fructose-sorbitol ingestion provokes gastrointestinal symptoms in patients with ED's.

I thought this recent study was pretty interesting, considering that I developed some stomach issues for the first time after relapsing into AN several years ago. My GP didn't understand why I would suddenly be having symptoms resembling celiac, IBS, etc. after ruling those out.

This was the conclusion of the study:
"Fructose-Sorbitol, but not glucose, provokes GI symptoms in ED patients, predominantly those with low BMI (17.5 or less). These findings are important in the dietary management of ED patients."

http://www.sciencedaily.com/releases/2009/11/091119101215.htm

How to Execute Dietary Management in Eating Disorder Patients

ScienceDaily (Nov. 18, 2009) — Eating disorders (ED) patients display a high prevalence of gastrointestinal symptoms and functional gastrointestinal disorders such as irritable bowel syndrome. These symptoms may interfere with their nutritional management. Ingestion of fructose-sorbitol (F-S) is an established means of gastrointestinal symptom provocation in irritable bowel syndrome patients. Surprisingly, although ED patients are known to consume "diet" products containing fructose and sorbitol, their gastrointestinal symptom responses to F-S provocation have not been studied.

A research article published on November 14, 2009 in the World Journal of Gastroenterology describes the responses of 26 ED patients to F-S provocation. The research team, including Professors Kellow, Abraham and Hansen from the University of Sydney, Australia, monitored gastrointestinal symptoms and breath hydrogen concentration (a marker of small bowel absorption) for 3 h following ingestion of 50 g glucose on one day, and 25 g fructose/5 g sorbitol on the next day. Responses to F-S were compared to those of 20 asymptomatic healthy females.
F-S provoked gastrointestinal symptoms in 15 ED patients but only in one healthy control. In contrast, only one ED patient displayed symptom provocation to glucose, which does not usually provoke gastrointestinal symptoms; this shows specificity of the F-S response. A greater symptom response was observed in the most underweight ED patients (BMI ≤ 17.5 kg/m2) compared to those with a BMI >17.5 kg/m2. There were no differences in psychological scores, prevalence of functional gastrointestinal disorders or breath hydrogen responses between patients with and without an F-S response.
The key findings of this study are that F-S provoked gastrointestinal symptoms in more than half of the female ED patients, a significantly greater proportion than that found in healthy individuals; the response was specific for F-S ingestion; and there was a greater symptom response in patients at lower BMI values. Consistent with this last finding, symptom provocation was more common in anorexia nervosa patients. Hence negative energy balance appears to play a role in F-S sensitivity in these patients. As fructose and sorbitol are likely to be commonly ingested by ED patients, representing a potential source of gastrointestinal distress that would impact negatively on their nutritional management, F-S provocative testing could prove valuable in identifying those patients with symptom sensitivity to these substances


In other words, sometimes the diet products and artificial sweeteners ED patients use can be contributing to GI symptoms that are difficult to explain. For some reason, the correlation between low BMI and sorbitol malabsorption had never been studied before. Kind-of relevant to the dietary treatment of ED patients, don't you think?
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