blue_mantra (blue_mantra) wrote in ed_ucate,

SSRIs, serotonin, appetite etc.

Okay, so I double checked the rules and hope this is okay... I have tried asking my doctor before but found them a little evasive.

Having re-read a few posts here, I saw a couple of members posting about serotonin and appetite and such.

Basically, I am confused about serotonin and its mechanisms. In the aforementioned post, the user referenced serotonin and the gut, as if it was a chemical working directly there. What I also 'know' is that SSRIs inhibit the reuptake of serotonin by the synapses in the brain. What is going on here? Does this mean there is more serotonin floating around or less?

I am very confused because my doctor tells me SSRIs don't affect weight, but I know many people who have been or are and all but one of these people (whol lost weight) have gained weight. I myself gained 10 pounds in six months when I was put on citalopram three years ago, and adding another 10-15 over the next year, before stabalising.

I just want to understand a little better, and many of you seem very clued up. I'm trying very hard, three years on, to accept the weight gain, but constantly wonder whether the slight reduction in anxiety stopped my body burning everything up/giving me terrible stomach problems, or whether it is/was chemical and directly related to the serotonin rather than a side effect from the change in mood.

I have tried articles through my (ex) university library etc. but I took an English Literature degree so I'm a little lacking in this area! Sorry if I sound like a total moron.


I found the trigger for my question:

"A lot of individual factors control how easily one can vomit... nervous system, hormones & gastric anatomy all play a role.

While I am capable of purging it is very difficult. I tend to not become nauseated easily, even if I consume an incredible volume of food or calories. I wonder if how easily one becomes nauseated relates to how easily one can vomit. Serotonin is strongly implicated in nausea/vomitting as well as satiety (most antiemetics block gastric serotonin receptors) perhaps individual variation in amount or type of serotonin receptors is involved.

If I remember correctly you were able to relate to my experience of feeling profoundly depressed eating carbohydrate. Maybe there is a link between how we metabolize food (or certain foods) and mood, satiety, even tendency to nausea/vomitting?"

Italics mine...


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